Back to Search Results

Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients.

Experimental and Clinical Research Center, a joint cooperation of Max Delbruck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, Berlin, Germany. Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany. Max Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany. Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin, Germany. Department of Internal and Integrative Medicine, Immanuel Krankenhaus Berlin, Berlin, Germany. Berlin Institute of Health (BIH), Berlin, Germany. Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Nephrology and Internal Intensive Care Medicine, Berlin, Germany. VIB Laboratory of Translational Immunomodulation, VIB Center for Inflammation Research (IRC), UHasselt, Campus Diepenbeek, Hasselt, Belgium. Department of Immunology, Biomedical Research Institute, UHasselt, Campus Diepenbeek, Hasselt, Belgium. Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany. Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany. Hannover Medical School, Hannover, Germany. Department of Cardiology and Nephrology, HELIOS-Klinikum, Berlin, Germany. Department of Biomedical Engineering, McConnell Brain Imaging Centre, Montreal Neurological Institute, Faculty of Medicine, McGill University, Montreal, Canada. Mila - Quebec Artificial Intelligence Institute, Montreal, Canada. Parietal Team, Institut National de Recherche en Informatique et en Automatique (INRIA), Neurospin, Commissariat à l'Energie Atomique (CEA) Saclay, Gif-sur-Yvette, France. Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. andreas.michalsen@charite.de. Department of Internal and Integrative Medicine, Immanuel Krankenhaus Berlin, Berlin, Germany. andreas.michalsen@charite.de. Experimental and Clinical Research Center, a joint cooperation of Max Delbruck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, Berlin, Germany. dominik.mueller@mdc-berlin.de. Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. dominik.mueller@mdc-berlin.de. DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany. dominik.mueller@mdc-berlin.de. Max Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany. dominik.mueller@mdc-berlin.de. Experimental and Clinical Research Center, a joint cooperation of Max Delbruck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, Berlin, Germany. sofia.forslund@mdc-berlin.de. Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. sofia.forslund@mdc-berlin.de. DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany. sofia.forslund@mdc-berlin.de. Max Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany. sofia.forslund@mdc-berlin.de.

Nature communications. 2021;(1):1970
Full text from:

Other resources

Abstract

Periods of fasting and refeeding may reduce cardiometabolic risk elevated by Western diet. Here we show in the substudy of NCT02099968, investigating the clinical parameters, the immunome and gut microbiome exploratory endpoints, that in hypertensive metabolic syndrome patients, a 5-day fast followed by a modified Dietary Approach to Stop Hypertension diet reduces systolic blood pressure, need for antihypertensive medications, body-mass index at three months post intervention compared to a modified Dietary Approach to Stop Hypertension diet alone. Fasting alters the gut microbiome, impacting bacterial taxa and gene modules associated with short-chain fatty acid production. Cross-system analyses reveal a positive correlation of circulating mucosa-associated invariant T cells, non-classical monocytes and CD4+ effector T cells with systolic blood pressure. Furthermore, regulatory T cells positively correlate with body-mass index and weight. Machine learning analysis of baseline immunome or microbiome data predicts sustained systolic blood pressure response within the fasting group, identifying CD8+ effector T cells, Th17 cells and regulatory T cells or Desulfovibrionaceae, Hydrogenoanaerobacterium, Akkermansia, and Ruminococcaceae as important contributors to the model. Here we report that the high-resolution multi-omics data highlight fasting as a promising non-pharmacological intervention for the treatment of high blood pressure in metabolic syndrome patients.